Total synthesis and structural revision of (+)-muironolide a.
نویسندگان
چکیده
Muironolide A is a fascinating tetrachlorinated marine polyketide isolated from the sponge of Phorbas sp. Only 90 μg had been isolated, and the structure was established by nanoscale NMR techniques. Herein we report the total synthesis of the substance with the assigned structure of muironolide A, propose a revised structure based on NMR data, and complete the enantioselective total synthesis of muironolide A.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 137 18 شماره
صفحات -
تاریخ انتشار 2015